Development of Validated Bioanalytical RP-HPLC Method for Determination of Sofosbuvir In Human Plasma
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چکیده
منابع مشابه
Development and Validation of a HPLC Method for Determination of Pefloxacin in Tablet and Human Plasma
Objective(s) Developing and validating a simple, efficient, reproducible and economic reversed phase high performance liquid chromatographic (RP-HPLC) method for the quantitative determination of pefloxacin in bulk material, tablets and in human plasma. Materials and Methods A shim-pack CLC-ODS column and a mobile phase constituting acetonitrile: 0.025 M phosphoric acid solution (13:87 v/v, ...
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The aim of the study was to develop a bioanalytical method for the determination of temozolomide (TMZ) in human plasma. Plasma concentration of TMZ was determined on a C18 column after liquid-liquid extraction. Isocratic elution was applied with the mixture of aqueous acetic acid and methanol. Theophylline was used as the internal standard. To prevent chemical degradation of TMZ at physiologica...
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Cefuroxime, (6R,7R)-3-(carbamoyloxymethyl) -7-{[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl] amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene2-carboxylic acid (CEF, Fig. 1, R = H), is a secondgeneration cephalosporin used against different kinds of bacterial infections. Cefuroxime axetil (CEFA) is its 1-acetyloxyethyl ester. After oral administration, CEFA is absorbed from the gastrointestinal tra...
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Objective: This study points to build up and validate a simple methodology to quantify the most used drug sofosbuvir for the treatment of hepatitis C virus (HCV) infection, in human plasma by using atazanavir as an Internal Standard (IS) for preclinical studies and validate as per USFDA guidelines. Methods: Sofosbuvir was isolated from plasma samples by liquid-liquid extraction method using ace...
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ژورنال
عنوان ژورنال: American Journal of PharmTech Research
سال: 2020
ISSN: 2249-3387
DOI: 10.46624/ajptr.2020.v10.i2.007